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Pharmacogenetics refers to a branch of science that researches the implications of genetic makeup in the response to medications in an individual. Ultimately, pharmacogenetics will be able to identify variations in the genes that translate to differences in drug metabolism, efficacy, and safety. At this juncture, pharmacogenetics may enable the customization of medicines with the intent of lessening adverse drug reactions (ADRs). This blog explores the working of pharmacogenetics in preventing adverse drug reactions, improving patient safety, and optimizing the therapeutic efficacy of drugs.